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Spatial proteomics is a term describing a wide variety of methods used to generate highly multiplexed images of specimens to characterise their protein composition and spatial organisation.  Unlike traditional proteomics which average results and lose spatial context, spatial proteomics reveals protein distributions (and hence cell properties) across intact tissue slices, enabling a detailed understanding of protein/cell networks, spatial relationships, and how local microenvironments influence and change with biological processes and disease.

The Imaging Facility's spatial proteomics platform is a Miltenyi MACSima. Using cyclic immunofluorescence (cycIF), this system can theoretically image an unlimited number of targets in one sample with the sequential addition, imaging and removal of labelled antibodies. The system is fully automated, uses samples prepared on standard microscope slides and does not require the use of proprietary antibodies.

Our system: